Regioselective thioacetylation of chitosan end-groups for nanoparticle gene delivery systems

Regioselective thioacetylation of chitosan end-groups for nanoparticle gene delivery systems† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00038f Click here for additional data file.

Chitosan for Gene Delivery and Orthopedic Tissue

Gene therapy involves the introduction of foreign genetic material into cells in order exert a therapeutic effect. The application of gene therapy to the field of orthopaedic tissue engineering is extremely promising as the controlled release of therapeutic proteins such as bone morphogenetic proteins have been shown to stimulate bone repair. However, there are a number of drawbacks associated ...

Chitosan-based Drug Delivery Systems

The most important characteristics of chitosans, which make them useful as delivery vectors for drugs and therapeutic proteins, are their excellent mucoadhesive and absorption enhancing properties [1-3]. The mucoadhesion is due to the electrostatic interaction between the positive charge on the chitosan polymer and the negatively charged sialic acid residues on the mucosal surface [4]. Because ...

Chitosan nanoparticle-based delivery of fused NKG2D–IL-21 gene suppresses colon cancer growth in mice

Nanoparticles can be loaded with exogenous DNA for the potential expression of cytokines with immune-stimulatory function. NKG2D identifies major histocompatibility complex class I chain-related protein in human and retinoic acid early induced transcript-1 in mouse, which acts as tumor-associated antigens. Biologic agents based on interleukin 21 (IL-21) have displayed antitumor activities throu...

Ocular drug delivery by liposome-chitosan nanoparticle complexes (LCS-NP).

This study evaluated in vitro and in vivo a colloidal nanosystem with the potential to deliver drugs to the ocular surface. This nanosystem, liposome-chitosan nanoparticle complexes (LCS-NP), was created as a complex between liposomes and chitosan nanoparticles (CS-NP). The conjunctival epithelial cell line IOBA-NHC was exposed to several concentrations of three different LCS-NP complex to dete...